Middlesex- this is the one based loosely on Eugenides, right?
Yes. It's a family saga. 
Interesting. With the mutated gene in the Greek family?
Yes. It's a very interesting story about nature and nurture. 
One of (if not the) oldest philosophical issues!
Exactly. It's not easy to have a mutated gene in the family.
Definitely not. It was highly received though, right? One of best books of 2002
The book was also featured in Oprah's Book Club in 2007.
Have you seen that she's got a talk show for her book club now?
I heard about it. The book discusses the pursuit of the American Dream and explores gender identity.